IAPP solution-dependent polymorphism and cross-aggregation – cryo-EM and MALDI-MSI

Unit / Facility

Cryo-EM / Spatial Mass Spectrometry

System / Target

Cryo-EM provides mechanistic insights into solution-dependent polymorphism and cross-aggregation of human and rat islet amyloid polypeptide; cryo-EM with spatial MS validation.

Organism / Source

Human / Rat IAPP

Approx. Data Collection Years

~2024–2025

Access / Reuse Status

Public

Main Public Repository / Storage

Publication (Biochemistry)

Techniques Used

Cryo-EM MS / Proteomics Spatial Mass Spectrometry Integrative / computational modelling (non-MD)

Repository Links

SciLifeLab Publication: SciLifeLab Publication
Publication: Biochemistry (2025)

Publications

Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides Biochemistry (2025) DOI: 10.1021/acs.biochem.5c00042 PubMed: 40417836

Cryo-EM with spatial mass spectrometry for IAPP fibril polymorphism and human–rat cross-aggregation.

Machine-Readable Metadata

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