IAPP mutant polymorphism – cryo-EM and integrative analysis

Unit / Facility

Cryo-EM / Integrated Microscopy Technologies Gothenburg / Bioinformatics

System / Target

Diverse polymorphism in IAPP (islet amyloid polypeptide) mutants; cryo-EM structures and computational analysis for peptide-based therapeutics.

Organism / Source

Human IAPP (amylin)

Approx. Data Collection Years

~2024–2025

Access / Reuse Status

Public

Main Public Repository / Storage

Publication (J. Mol. Biol.)

Cryo-EM Integrative / computational modelling (non-MD) Bioinformatics / Data Integration

Multimodal cryo-EM and computational analysis of IAPP fibril polymorphism to inform design of peptide-based therapeutics.