ApoA-I amyloidogenic variants - structure dynamics in small HDL

Unit / Facility

Swedish NMR Centre / Mass spectrometry

System / Target

Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux; HDX-MS and structural analysis.

Organism / Source

Human ApoA-I / HDL

Approx. Data Collection Years

~2019–2020

Access / Reuse Status

Public

Main Public Repository / Storage

J. Lipid Res.; PRIDE (public HDX dataset)

Techniques Used

MS / Proteomics Biophysics (ITC/SPR/MST/DSF etc.) Integrative / computational modelling (non-MD)

Repository Links

SciLifeLab Publication: SciLifeLab Publication
Publication: J. Lipid Res. (2020)

Publications

Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux J. Lipid Res. (2020) DOI: 10.1194/jlr.RA120000920 PubMed: 33410751

HDX-MS of ApoA-I variants. From the publication list.

Machine-Readable Metadata

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