{
  "id": "ISB-D-0008",
  "portal_index": 8,
  "title": "Yeast Nuclear Pore Complex - CX-MS",
  "portal_description": "Comprehensive structure and functional adaptations of the yeast nuclear pore complex using cross-linking mass spectrometry and integrative modeling.",
  "portal_landing_page_url": "https://wpotrzebowski.github.io/isb_datasets/datasets/dataset-9.html",
  "unit_facility": "Structural Proteomics / Integrative Structural Biology",
  "system_target": "Comprehensive structure and functional adaptations of the yeast nuclear pore complex using cross-linking mass spectrometry and integrative modeling.",
  "organism_source": "Saccharomyces cerevisiae",
  "approx_data_collection_years": "~2020–2021",
  "access": {
    "status": "public",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/"
  },
  "main_public_repository_storage": "Zenodo + PDB + PDB-IHM",
  "techniques": [
    {
      "code": "xl_ms",
      "label": "Cross-linking MS (XL-MS)"
    },
    {
      "code": "cryo_em",
      "label": "Cryo-EM"
    },
    {
      "code": "integrative_modelling",
      "label": "Integrative / computational modelling (non-MD)"
    },
    {
      "code": "ms_proteomics",
      "label": "MS / Proteomics"
    }
  ],
  "repository_records": [
    {
      "kind": "Zenodo",
      "accession": "5721514",
      "doi": "10.5281/zenodo.5721514",
      "url": "https://doi.org/10.5281/zenodo.5721514",
      "relation": "primary_dataset",
      "note": "Portal links to Zenodo record 5721514 (CX-MS datasets)."
    },
    {
      "kind": "PDB-IHM",
      "accession": "8ZZC",
      "url": "https://pdb-ihm.org/entry.html?8ZZC",
      "relation": "related_structure",
      "note": "Integrative structure of 8 NPC spokes (CX-MS, cryo-ET, SAS)"
    },
    {
      "kind": "PDB-IHM",
      "accession": "9A0F",
      "url": "https://pdb-ihm.org/entry.html?9A0F",
      "relation": "related_structure",
      "note": "Integrative model of wild-type yeast NPC"
    },
    {
      "kind": "PDB",
      "accession": null,
      "url": null,
      "relation": "structure_models",
      "note": "Portal lists PDB as a main repository; 7N85, 7WOO from Cell (2022) paper."
    }
  ],
  "publications": [
    {
      "type": "journal_article_or_preprint",
      "title": "Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex",
      "doi": null,
      "url": null,
      "relation": "primary_publication",
      "note": "Portal lists the publication title but not DOI."
    }
  ],
  "keywords": [
    "nuclear pore complex",
    "yeast",
    "Saccharomyces cerevisiae",
    "cross-linking MS",
    "integrative modelling"
  ]
}