{
  "id": "ISB-D-0003",
  "portal_index": 3,
  "title": "MUC2 CysD2 domain",
  "portal_description": "Second CysD domain (CysD2) from intestinal mucin MUC2; NMR solution structure, SAXS and MS/MST to understand mucin network organisation and cross-linking.",
  "portal_landing_page_url": "https://wpotrzebowski.github.io/isb_datasets/datasets/dataset-3.html",
  "unit_facility": "Swedish NMR Centre (Gothenburg) + MPE core",
  "system_target": "Second CysD domain (CysD2) from intestinal mucin MUC2; NMR solution structure, SAXS and MS/MST to understand mucin network organisation and cross-linking.",
  "organism_source": "Human MUC2 domain",
  "approx_data_collection_years": "~2021–2024",
  "access": {
    "status": "public",
    "license": null,
    "license_url": null
  },
  "main_public_repository_storage": "PDB + SASBDB + journal SI (+ proteomics repository)",
  "techniques": [
    {
      "code": "saxs",
      "label": "SAXS"
    },
    {
      "code": "nmr",
      "label": "NMR"
    },
    {
      "code": "ms_proteomics",
      "label": "MS / Proteomics"
    },
    {
      "code": "biophysics",
      "label": "Biophysics (ITC/SPR/MST/DSF etc.)"
    },
    {
      "code": "integrative_modelling",
      "label": "Integrative / computational modelling (non-MD)"
    }
  ],
  "repository_records": [
    {
      "kind": "PDB",
      "accession": "8S03",
      "url": "https://www.rcsb.org/structure/8S03",
      "relation": "primary_structure"
    },
    {
      "kind": "BMRB",
      "accession": "34899",
      "url": "https://bmrb.io/34899",
      "relation": "primary_nmr_data",
      "derived_from": "PDB:8S03"
    },
    {
      "kind": "SASBDB",
      "accession": "SASDSG5",
      "url": "https://www.sasbdb.org/data/SASDSG5/",
      "relation": "saxs_sans_profile"
    },
    {
      "kind": "MS repository",
      "accession": null,
      "url": null,
      "relation": "proteomics_dataset",
      "note": "Portal indicates an MS dataset (likely PRIDE/ProteomeXchange) exists but ID was not yet added."
    }
  ],
  "publications": [
    {
      "type": "journal_article",
      "venue": "Cell Reports (2024)",
      "doi": "10.1016/j.celrep.2024.114207",
      "url": "https://doi.org/10.1016/j.celrep.2024.114207",
      "relation": "primary_publication",
      "citation": "Cell Reports 43:114207 (2024)"
    }
  ],
  "keywords": [
    "MUC2",
    "mucin",
    "CysD domain",
    "NMR",
    "cross-linking"
  ]
}